Schedule
| Day | Game | Visitor Team | Score | Home Team | Score | Overtime | Shoot Out | Game Details |
|---|---|---|---|---|---|---|---|---|
| 1 | 4 | Montreal Canadiens | 4 | Buffalo Sabres | 2 | - | - | Scores |
| 4 | 22 | Buffalo Sabres | 3 | Detroit Red Wings | 4 | True | - | Scores |
| 6 | 40 | Columbus Blue Jackets | 1 | Buffalo Sabres | 3 | - | - | Scores |
| 8 | 50 | Buffalo Sabres | 4 | Toronto Maple Leafs | 3 | - | - | Scores |
| 10 | 66 | Buffalo Sabres | 1 | Ottawa Senators | 2 | True | True | Scores |
| 12 | 79 | Buffalo Sabres | 3 | Tampa Bay Lightning | 5 | - | - | Scores |
| 14 | 93 | Tampa Bay Lightning | 4 | Buffalo Sabres | 2 | - | - | Scores |
| 17 | 111 | Buffalo Sabres | 3 | Florida Panthers | 1 | - | - | Scores |
| 19 | 126 | Detroit Red Wings | 3 | Buffalo Sabres | 4 | True | - | Scores |
| 21 | 147 | Boston Bruins | 4 | Buffalo Sabres | 5 | - | - | Scores |
| 23 | 158 | Buffalo Sabres | 5 | Boston Bruins | 4 | True | True | Scores |
| 26 | 176 | Toronto Maple Leafs | 2 | Buffalo Sabres | 3 | True | True | Scores |
| 28 | 192 | Buffalo Sabres | 4 | Montreal Canadiens | 2 | - | - | Scores |
| 31 | 216 | Ottawa Senators | 6 | Buffalo Sabres | 5 | - | - | Scores |
| 33 | 231 | Buffalo Sabres | 3 | Carolina Hurricanes | 5 | - | - | Scores |
| 34 | 242 | Florida Panthers | 4 | Buffalo Sabres | 5 | True | - | Scores |
| 37 | 266 | Ottawa Senators | 0 | Buffalo Sabres | 0 | - | - | |
| 39 | 279 | Buffalo Sabres | 0 | San Jose Sharks | 0 | - | - | |
| 41 | 289 | Buffalo Sabres | 0 | New York Rangers | 0 | - | - | |
| 43 | 308 | Colorado Avalanche | 0 | Buffalo Sabres | 0 | - | - | |
| 45 | 319 | Buffalo Sabres | 0 | Calgary Flames | 0 | - | - | |
| 47 | 337 | Florida Panthers | 0 | Buffalo Sabres | 0 | - | - | |
| 50 | 362 | Los Angeles Kings | 0 | Buffalo Sabres | 0 | - | - | |
| 52 | 380 | Buffalo Sabres | 0 | Edmonton Oilers | 0 | - | - | |
| 54 | 390 | Buffalo Sabres | 0 | Columbus Blue Jackets | 0 | - | - | |
| 56 | 404 | Columbus Blue Jackets | 0 | Buffalo Sabres | 0 | - | - | |
| 58 | 421 | Buffalo Sabres | 0 | Tampa Bay Lightning | 0 | - | - | |
| 60 | 435 | New York Islanders | 0 | Buffalo Sabres | 0 | - | - | |
| 62 | 450 | Buffalo Sabres | 0 | Utah Mammoth | 0 | - | - | |
| 64 | 463 | Buffalo Sabres | 0 | Detroit Red Wings | 0 | - | - | |
| 66 | 479 | Toronto Maple Leafs | 0 | Buffalo Sabres | 0 | - | - | |
| 68 | 496 | Edmonton Oilers | 0 | Buffalo Sabres | 0 | - | - | |
| 70 | 517 | Buffalo Sabres | 0 | Chicago Blackhawks | 0 | - | - | |
| 73 | 532 | Nashville Predators | 0 | Buffalo Sabres | 0 | - | - | |
| 75 | 553 | Buffalo Sabres | 0 | Carolina Hurricanes | 0 | - | - | |
| 76 | 564 | Buffalo Sabres | 0 | Boston Bruins | 0 | - | - | |
| 77 | 572 | Pittsburgh Penguins | 0 | Buffalo Sabres | 0 | - | - | |
| 80 | 595 | Boston Bruins | 0 | Buffalo Sabres | 0 | - | - | |
| 83 | 615 | Buffalo Sabres | 0 | New York Rangers | 0 | - | - | |
| 84 | 626 | Philadelphia Flyers | 0 | Buffalo Sabres | 0 | - | - | |
| 87 | 642 | Buffalo Sabres | 0 | Florida Panthers | 0 | - | - | |
| 89 | 659 | Florida Panthers | 0 | Buffalo Sabres | 0 | - | - | |
| 91 | 677 | Buffalo Sabres | 0 | Detroit Red Wings | 0 | - | - | |
| 93 | 689 | Vegas Golden Knights | 0 | Buffalo Sabres | 0 | - | - | |
| 95 | 706 | Buffalo Sabres | 0 | Seattle Kraken | 0 | - | - | |
| 97 | 717 | Buffalo Sabres | 0 | Minnesota Wild | 0 | - | - | |
| 99 | 728 | Buffalo Sabres | 0 | Boston Bruins | 0 | - | - | |
| 100 | 735 | Toronto Maple Leafs | 0 | Buffalo Sabres | 0 | - | - | |
| 104 | 762 | Ottawa Senators | 0 | Buffalo Sabres | 0 | - | - | |
| 105 | 774 | Buffalo Sabres | 0 | Tampa Bay Lightning | 0 | - | - | |
| 108 | 792 | Philadelphia Flyers | 0 | Buffalo Sabres | 0 | - | - | |
| 111 | 816 | Carolina Hurricanes | 0 | Buffalo Sabres | 0 | - | - | |
| 113 | 829 | Buffalo Sabres | 0 | Washington Capitals | 0 | - | - | |
| 115 | 840 | Buffalo Sabres | 0 | Florida Panthers | 0 | - | - | |
| 117 | 857 | Washington Capitals | 0 | Buffalo Sabres | 0 | - | - | |
| 119 | 879 | Columbus Blue Jackets | 0 | Buffalo Sabres | 0 | - | - | |
| 121 | 892 | Buffalo Sabres | 0 | Washington Capitals | 0 | - | - | |
| 123 | 907 | Buffalo Sabres | 0 | Montreal Canadiens | 0 | - | - | |
| 125 | 919 | Pittsburgh Penguins | 0 | Buffalo Sabres | 0 | - | - | |
| 126 | 935 | Buffalo Sabres | 0 | Pittsburgh Penguins | 0 | - | - | |
| 128 | 950 | New Jersey Devils | 0 | Buffalo Sabres | 0 | - | - | |
| 131 | 970 | Buffalo Sabres | 0 | New Jersey Devils | 0 | - | - | |
| 132 | 982 | Boston Bruins | 0 | Buffalo Sabres | 0 | - | - | |
| 135 | 1007 | Winnipeg Jets | 0 | Buffalo Sabres | 0 | - | - | |
| 136 | 1015 | Buffalo Sabres | 0 | St.Louis Blues | 0 | - | - | |
| 139 | 1038 | New York Rangers | 0 | Buffalo Sabres | 0 | - | - | |
| 141 | 1045 | Buffalo Sabres | 0 | Montreal Canadiens | 0 | - | - | |
| 144 | 1071 | Dallas Stars | 0 | Buffalo Sabres | 0 | - | - | |
| 147 | 1085 | Buffalo Sabres | 0 | Philadelphia Flyers | 0 | - | - | |
| 149 | 1104 | Detroit Red Wings | 0 | Buffalo Sabres | 0 | - | - | |
| 151 | 1116 | Buffalo Sabres | 0 | New York Islanders | 0 | - | - | |
| 153 | 1132 | Buffalo Sabres | 0 | Ottawa Senators | 0 | - | - | |
| 155 | 1145 | Anaheim Ducks | 0 | Buffalo Sabres | 0 | - | - | |
| 158 | 1167 | New Jersey Devils | 0 | Buffalo Sabres | 0 | - | - | |
| 159 | 1176 | Buffalo Sabres | 0 | Vancouver Canucks | 0 | - | - | |
| 162 | 1200 | Montreal Canadiens | 0 | Buffalo Sabres | 0 | - | - | |
| 165 | 1226 | Montreal Canadiens | 0 | Buffalo Sabres | 0 | - | - | |
| 166 | 1229 | Buffalo Sabres | 0 | Toronto Maple Leafs | 0 | - | - | |
| 170 | 1261 | Tampa Bay Lightning | 0 | Buffalo Sabres | 0 | - | - | |
| 171 | 1266 | Buffalo Sabres | 0 | New York Islanders | 0 | - | - | |
| 176 | 1290 | Tampa Bay Lightning | 0 | Buffalo Sabres | 0 | - | - | |
| 177 | 1300 | Buffalo Sabres | 0 | Toronto Maple Leafs | 0 | - | - | |
| 182 | 1324 | Detroit Red Wings | 0 | Buffalo Sabres | 0 | - | - | |
| 183 | 1330 | Buffalo Sabres | 0 | Ottawa Senators | 0 | - | - |