Schedule
| Day | Game | Visitor Team | Score | Home Team | Score | Overtime | Shoot Out | Game Details |
|---|---|---|---|---|---|---|---|---|
| 1 | 4 | Buffalo Sabres | 2 | Detroit Red Wings | 3 | - | - | Scores |
| 3 | 20 | Buffalo Sabres | 1 | Toronto Maple Leafs | 5 | - | - | Scores |
| 4 | 30 | Carolina Hurricanes | 3 | Buffalo Sabres | 2 | True | True | Scores |
| 8 | 54 | Buffalo Sabres | 3 | Boston Bruins | 4 | - | - | Scores |
| 9 | 63 | Florida Panthers | 5 | Buffalo Sabres | 3 | - | - | Scores |
| 12 | 83 | Tampa Bay Lightning | 1 | Buffalo Sabres | 3 | - | - | Scores |
| 15 | 106 | Philadelphia Flyers | 4 | Buffalo Sabres | 3 | True | True | Scores |
| 18 | 126 | Buffalo Sabres | 3 | Ottawa Senators | 4 | True | True | Scores |
| 19 | 137 | Buffalo Sabres | 3 | Montreal Canadiens | 2 | - | - | Scores |
| 21 | 150 | Chicago Blackhawks | 5 | Buffalo Sabres | 4 | - | - | Scores |
| 23 | 169 | Philadelphia Flyers | 5 | Buffalo Sabres | 2 | - | - | Scores |
| 26 | 194 | Buffalo Sabres | 3 | New York Rangers | 4 | True | True | Scores |
| 28 | 202 | Buffalo Sabres | 2 | Ottawa Senators | 4 | - | - | Scores |
| 29 | 213 | Montreal Canadiens | 2 | Buffalo Sabres | 1 | True | True | Scores |
| 32 | 233 | Buffalo Sabres | 2 | Boston Bruins | 1 | - | - | Scores |
| 33 | 244 | Detroit Red Wings | 3 | Buffalo Sabres | 5 | - | - | Scores |
| 36 | 265 | Edmonton Oilers | 3 | Buffalo Sabres | 2 | True | True | Scores |
| 40 | 293 | Montreal Canadiens | 2 | Buffalo Sabres | 3 | True | True | Scores |
| 42 | 305 | Buffalo Sabres | 2 | Florida Panthers | 3 | - | - | Scores |
| 44 | 322 | Buffalo Sabres | 2 | Boston Bruins | 1 | - | - | Scores |
| 46 | 335 | Chicago Blackhawks | 3 | Buffalo Sabres | 1 | - | - | Scores |
| 49 | 355 | San Jose Sharks | 8 | Buffalo Sabres | 2 | - | - | Scores |
| 51 | 376 | Buffalo Sabres | 3 | Nashville Predators | 2 | True | True | Scores |
| 53 | 391 | Utah Mammoth | 2 | Buffalo Sabres | 3 | - | - | Scores |
| 55 | 399 | Buffalo Sabres | 5 | Washington Capitals | 6 | - | - | Scores |
| 57 | 412 | Buffalo Sabres | 0 | Carolina Hurricanes | 1 | - | - | Scores |
| 58 | 427 | New York Islanders | 2 | Buffalo Sabres | 7 | - | - | Scores |
| 61 | 445 | Buffalo Sabres | 1 | Minnesota Wild | 4 | - | - | Scores |
| 62 | 460 | Detroit Red Wings | 6 | Buffalo Sabres | 1 | - | - | Scores |
| 65 | 479 | Buffalo Sabres | 1 | Minnesota Wild | 4 | - | - | Scores |
| 67 | 489 | Buffalo Sabres | 1 | Colorado Avalanche | 3 | - | - | Scores |
| 68 | 501 | Tampa Bay Lightning | 3 | Buffalo Sabres | 4 | True | True | Scores |
| 71 | 522 | Philadelphia Flyers | 2 | Buffalo Sabres | 5 | - | - | Scores |
| 74 | 541 | Buffalo Sabres | 4 | Calgary Flames | 1 | - | - | Scores |
| 76 | 557 | Ottawa Senators | 1 | Buffalo Sabres | 4 | - | - | Scores |
| 79 | 582 | Ottawa Senators | 4 | Buffalo Sabres | 5 | - | - | Scores |
| 81 | 590 | Buffalo Sabres | 6 | New York Rangers | 2 | - | - | Scores |
| 84 | 615 | Washington Capitals | 7 | Buffalo Sabres | 3 | - | - | Scores |
| 86 | 629 | Buffalo Sabres | 1 | Ottawa Senators | 3 | - | - | Scores |
| 88 | 642 | Buffalo Sabres | 2 | Tampa Bay Lightning | 3 | - | - | Scores |
| 90 | 653 | Buffalo Sabres | 11 | Vancouver Canucks | 2 | - | - | Scores |
| 91 | 660 | Dallas Stars | 5 | Buffalo Sabres | 1 | - | - | Scores |
| 94 | 683 | Washington Capitals | 1 | Buffalo Sabres | 4 | - | - | Scores |
| 96 | 702 | Buffalo Sabres | 2 | New York Islanders | 3 | - | - | Scores |
| 98 | 713 | Buffalo Sabres | 5 | Montreal Canadiens | 1 | - | - | Scores |
| 99 | 724 | Florida Panthers | 0 | Buffalo Sabres | 1 | - | - | Scores |
| 102 | 748 | Pittsburgh Penguins | 5 | Buffalo Sabres | 4 | True | True | Scores |
| 104 | 758 | Buffalo Sabres | 6 | Toronto Maple Leafs | 4 | - | - | Scores |
| 106 | 769 | Buffalo Sabres | 5 | Tampa Bay Lightning | 3 | - | - | Scores |
| 108 | 786 | Carolina Hurricanes | 4 | Buffalo Sabres | 2 | - | - | Scores |
| 112 | 805 | Buffalo Sabres | 2 | Vegas Golden Knights | 4 | - | - | Scores |
| 114 | 821 | New York Islanders | 6 | Buffalo Sabres | 2 | - | - | Scores |
| 117 | 842 | Buffalo Sabres | 2 | Florida Panthers | 3 | True | True | Scores |
| 119 | 854 | Carolina Hurricanes | 3 | Buffalo Sabres | 5 | - | - | Scores |
| 121 | 870 | Buffalo Sabres | 1 | Seattle Kraken | 4 | - | - | Scores |
| 122 | 879 | Buffalo Sabres | 4 | Columbus Blue Jackets | 1 | - | - | Scores |
| 124 | 888 | Tampa Bay Lightning | 0 | Buffalo Sabres | 0 | - | - | |
| 127 | 914 | Buffalo Sabres | 0 | Philadelphia Flyers | 0 | - | - | |
| 128 | 921 | Anaheim Ducks | 0 | Buffalo Sabres | 0 | - | - | |
| 131 | 946 | Toronto Maple Leafs | 0 | Buffalo Sabres | 0 | - | - | |
| 133 | 955 | Buffalo Sabres | 0 | Winnipeg Jets | 0 | - | - | |
| 136 | 979 | St.Louis Blues | 0 | Buffalo Sabres | 0 | - | - | |
| 138 | 997 | Buffalo Sabres | 0 | New Jersey Devils | 0 | - | - | |
| 140 | 1009 | Toronto Maple Leafs | 0 | Buffalo Sabres | 0 | - | - | |
| 142 | 1019 | Buffalo Sabres | 0 | Edmonton Oilers | 0 | - | - | |
| 145 | 1044 | New Jersey Devils | 0 | Buffalo Sabres | 0 | - | - | |
| 148 | 1065 | Buffalo Sabres | 0 | Montreal Canadiens | 0 | - | - | |
| 149 | 1077 | New York Rangers | 0 | Buffalo Sabres | 0 | - | - | |
| 152 | 1101 | Los Angeles Kings | 0 | Buffalo Sabres | 0 | - | - | |
| 153 | 1109 | Buffalo Sabres | 0 | Toronto Maple Leafs | 0 | - | - | |
| 156 | 1131 | Columbus Blue Jackets | 0 | Buffalo Sabres | 0 | - | - | |
| 158 | 1141 | Buffalo Sabres | 0 | Winnipeg Jets | 0 | - | - | |
| 160 | 1162 | Columbus Blue Jackets | 0 | Buffalo Sabres | 0 | - | - | |
| 162 | 1174 | Buffalo Sabres | 0 | Calgary Flames | 0 | - | - | |
| 165 | 1191 | Buffalo Sabres | 0 | Detroit Red Wings | 0 | - | - | |
| 168 | 1205 | New Jersey Devils | 0 | Buffalo Sabres | 0 | - | - | |
| 171 | 1227 | Boston Bruins | 0 | Buffalo Sabres | 0 | - | - | |
| 175 | 1253 | Florida Panthers | 0 | Buffalo Sabres | 0 | - | - | |
| 177 | 1264 | Buffalo Sabres | 0 | Detroit Red Wings | 0 | - | - | |
| 179 | 1280 | Buffalo Sabres | 0 | Pittsburgh Penguins | 0 | - | - | |
| 182 | 1295 | Boston Bruins | 0 | Buffalo Sabres | 0 | - | - | |
| 183 | 1304 | Buffalo Sabres | 0 | Pittsburgh Penguins | 0 | - | - |